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Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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A Guide to Administration of PEDIARIX for Nurses
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
[PEDIARIX logo (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine)] [GSK logo]
DR. LEN FRIEDLAND
A guide to the administration of PEDIARIX for Nurses.
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Dr. Leonard Friedland
VP, Scientific Affairs & Public Health
GSK Vaccines
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
Hi. My name is Len Friedland, and I’m the Vice President for Scientific Affairs and Public Health for GSK Vaccines. I’m a practicing pediatrician, fellowship trained in pediatric emergency medicine and a vaccine research scientist. Welcome to the eLecture series for PEDIARIX.
This series of videos will explore the clinical, financial, and organizational benefits of using PEDIARIX and the other GSK DTaP-containing vaccines for your appropriate patients.
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Supply Reliability
Schedule Flexibility
Efficacy and Safety
Customer Solutions
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
Some of these attributes include supply reliability, schedule flexibility, the efficacy of PEDIARIX and its safety profile, and customer solutions, including cost-savings programs.
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- Dosing
- Administration
- Storage
- Barcodes and CPT Codes
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
In this video, we’ll cover dosing, administration, and storage, as well as barcodes and CPT codes to help you better manage your PEDIARIX supply and your immunization schedule.
First, let’s take a look at the Indication for PEDIARIX.
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Indication for PEDIARIX
PEDIARIX is indicated for active immunization against diphtheria, tetanus, pertussis, infection caused by all known subtypes of hepatitis B virus, and poliomyelitis. PEDIARIX is approved for use as a 3-dose series in infants born of hepatitis B surface antigen-negative mothers. PEDIARIX may be given as early as 6 weeks of age through 6 years of age (prior to the seventh birthday).
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
PEDIARIX is indicated for active immunization against diphtheria, tetanus, pertussis, infection caused by all known subtypes of hepatitis B virus, and poliomyelitis. PEDIARIX is approved for use as a 3-dose series in infants born of hepatitis B surface antigen-negative mothers. PEDIARIX may be given as early as 6 weeks of age through 6 years of age (prior to the seventh birthday).
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GSK is here to provide solutions to help maintain the continuity of your well-established primary series DTaP immunization schedule.
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
We know your practice gets busy, and maintaining the vaccination scheduling for your pediatric patients is a top priority. GSK is here to provide solutions to help maintain the continuity of your well-established primary series DTaP immunization schedule.
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Continue your DTaP immunization routine without interruption with PEDIARIX
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
At GSK, we also understand how important it is to continue your DTaP immunization routine without interruption. As the cornerstone of GSK’s DTaP-containing vaccine portfolio since 2002, PEDIARIX is here to help maintain the continuity of your primary series DTaP immunization schedule.
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Complete the Primary DTaP Series with PEDIARIX1,2
[Chart showing vaccine needs and PEDIARIX coverage for first 6 months]
DTaP=diphtheria, tetanus, and acellular pertussis.
IPV=inactivated poliovirus vaccine.
References: 1. Recommended immunization schedule for children and adolescents aged 18 years or younger 2025. Centers for Disease Control and Prevention website.
Updated November 21,2024. Accessed November 26, 2024. 2. Prescribing Information for PEDIARIX.
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
PEDIARIX can be administered as early as 6 weeks of age, with the last dose given prior to the patient’s seventh birthday. For the primary vaccination series, PEDIARIX should be administered as an intramuscular injection at 2, 4, and 6 months of age. These three doses of PEDIARIX make up the primary immunization course for diphtheria, tetanus, pertussis, and poliomyelitis, and completes the course of vaccination against hepatitis B.
PEDIARIX is dosed at intervals of 6 to 8 weeks, preferably 8 weeks. Data are not available on the safety and effectiveness of using PEDIARIX following one or more doses of a DTaP vaccine from a different manufacturer.
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Color-coded to help with identification.
The tip cap of the prefilled syringes may or may not be made with natural rubber latex. Natural rubber latex may cause allergic reactions. Please check the carton.
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
PEDIARIX comes in a convenient 0.5-milliliter color-coded, single dose prefilled syringe. To help you reduce the steps in the administration process, the syringe is prefilled with a single-unit dose, and is color coded to help with identification. Please be aware that the tip caps of the prefilled syringes may or may not be made with natural rubber latex, which may cause allergic reactions. Please check the carton.
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2D barcodes contain the:
- National Drug Code (NDC) number
- Lot number
- Expiration date
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
To further help save you time and manage your vaccine supply, PEDIARIX has 2-D bar codes that contain the National Drug Code (or, NDC) number, lot number, and expiration date.
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More easily update your:
- Inventory management system
- Patient records
- Vaccination reports
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
With this additional information, you can more easily update your inventory management system, patient records, and vaccination reports through any compatible Electronic Medical Record or Electronic Health Record.
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2D barcodes contain the National Drug Code (NDC) numbers, lot number, and expiration date
- Syringe NDC: 58160-811-43
- Outer Carton (Package of 10) NDC: 58160-811-52
- CPT Code: 90723
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
For your convenience, all the information you need for charting is found on the carton, including the lot number, expiration date, UPC and 2-D bar codes, and the numbers for both the syringe and the outer carton. The CPT code for PEDIARIX is 90723.
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Preparation and Administration
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
GSK wants to help simplify all aspects of the vaccination process for your practice, which is why we’ve designed our vaccine packaging with you in mind. Now that we’ve talked about the packaging, let’s go over the administration process for PEDIARIX.
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Shake vigorously to get a homogenous, white suspension
Children <1: anterolateral aspect of thigh
Older Children: deltoid muscle
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
Shake PEDIARIX vigorously to obtain a homogenous, turbid, white suspension. Once mixed, attach a sterile needle to the syringe and administer the dose of PEDIARIX intramuscularly.
For children younger than 1 year of age, the preferred administration site is the anterolateral aspect of the thigh. In older children, the deltoid muscle is usually large enough for an intramuscular injection. PEDIARIX should not be injected in the gluteal area or in areas where there may be a major nerve.
Do not administer PEDIARIX intravenously, intradermally, or subcutaneously.
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Refrigerate between 2° and 8°C (36° and 46°F)
Do not freeze.
Discard if the vaccine has been frozen.
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
When storing your PEDIARIX supply, be sure to refrigerate between 2 and 8 degrees Celsius, that is, between 36 and 46 degrees Fahrenheit. If the vaccine has been frozen, do not use it, and be sure to dispose of it properly.
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Maximum discounts:
Cost savings programs with optimized group pricing and multiple contract options
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
Beyond supply, PEDIARIX supports your practice in other practical ways, with cost-savings programs such as optimized group pricing and multiple contract options. Contact your GSK Representative to learn more.
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Thank you for partnering with GSK and PEDIARIX
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
We hope this video provided you with a better understanding of the dosing, administration, packaging, and storage of PEDIARIX.
Thank you for partnering with GSK and PEDIARIX. We look forward to supplying the vaccines you need to help your patients and your practice.
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Continue your DTaP immunization routine without interruption with PEDIARIX.
Order PEDIARIX today: Call 1-866-475-8222. Visit GSKDirect.com or contact your GSK Sales Representative.
Schedule a GSK Vaccine Business Review today to find out more about our Premium Partner program. For more information about PEDIARIX, please see the Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
Please see Important Safety Information in this video and full Prescribing Information available at PEDIARIX.com.
[PEDIARIX logo (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine)] [GSK logo]
DR. LEN FRIEDLAND
Keep your DTaP immunization routine running smoothly. Order PEDIARIX today by calling 1-866-475-8222, by visiting GSKDirect.com, or by contacting your GSK Sales Representative.
Thank you for watching this video. For more information about PEDIARIX, please see the Important Safety Information and full Prescribing Information at PEDIARIX.com.
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Important Safety Information for PEDIARIX
- Contraindications for PEDIARIX are: severe allergic reaction (for example, anaphylaxis) after a previous dose of any diphtheria toxoid-, tetanus toxoid-, pertussis-, hepatitis B-, or poliovirus-containing vaccine, or to any component of PEDIARIX; encephalopathy within 7 days of administration of a previous pertussis-containing vaccine; progressive neurologic disorders
- In clinical trials, PEDIARIX was associated with higher rates of fever relative to separately administered vaccines
- The decision to give PEDIARIX should be based on potential benefits and risks if Guillain-Barré syndrome has occurred within 6 weeks of receipt of a prior vaccine containing tetanus toxoid, or if adverse events (such as, temperature ≥105oF, collapse or shock-like state, persistent, inconsolable crying lasting ≥3 hours, occurring within 48 hours after vaccination; seizures within 3 days after vaccination) have occurred after receipt of a pertussis-containing vaccine
Please see full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
Important Safety Information for PEDIARIX.
Contraindications for PEDIARIX are: severe allergic reaction (eg, anaphylaxis) after a previous dose of any diphtheria toxoid-, tetanus toxoid-, pertussis-, hepatitis B-, or poliovirus-containing vaccine, or to any component of PEDIARIX; encephalopathy within 7 days of administration of a previous pertussis-containing vaccine; progressive neurologic disorders.
In clinical trials, PEDIARIX was associated with higher rates of fever relative to separately administered vaccines.
The decision to give PEDIARIX should be based on potential benefits and risks if Guillain-Barré syndrome has occurred within 6 weeks of receipt of a prior vaccine containing tetanus toxoid, or if adverse events (ie, temperature ≥105oF, collapse or shock-like state, persistent, inconsolable crying lasting ≥3 hours, occurring within 48 hours after vaccination; seizures within 3 days after vaccination) have occurred after receipt of a pertussis-containing vaccine.
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Important Safety Information for PEDIARIX (cont’d)
- The tip cap of the prefilled syringe may or may not be made with natural rubber latex. Natural rubber latex may cause allergic reactions. Please check the carton
- Syncope (fainting) can occur in association with administration of injectable vaccines. Procedures should be in place to avoid falling injury and to restore cerebral perfusion following syncope
- For children at higher risk for seizures, an antipyretic may be administered at the time of vaccination with PEDIARIX
Please see full Prescribing Information available at PEDIARIX.com.
[PEDIARIX logo (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine)] [GSK logo]
DR. LEN FRIEDLAND
The tip cap of the prefilled syringe may or may not be made with natural rubber latex. Natural rubber latex may cause allergic reactions. Please check the carton.
Syncope (fainting) can occur in association with administration of injectable vaccines. Procedures should be in place to avoid falling injury and to restore cerebral perfusion following syncope.
For children at higher risk for seizures, an antipyretic may be administered at the time of vaccination with PEDIARIX.
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Important Safety Information for PEDIARIX (cont’d)
- Apnea following intramuscular vaccination has been observed in some infants born prematurely. Vaccination with PEDIARIX should be based on consideration of the individual infant's medical status and the potential benefits and possible risks of vaccination
- In clinical trials, common adverse reactions in infants receiving PEDIARIX included injection-site reactions (pain, redness, and swelling), fever, drowsiness, irritability/fussiness, and loss of appetite
- Vaccination with PEDIARIX may not result in protection in all vaccine recipients
Trademarks are owned by or licensed to the GSK group of companies.
©2024 GSK or licensor.
PMUS-PDRVID240005 November 2024
Produced in USA.
Please see full Prescribing Information available at PEDIARIX.com.
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DR. LEN FRIEDLAND
Apnea following intramuscular vaccination has been observed in some infants born prematurely. Vaccination with PEDIARIX should be based on consideration of the individual infant's medical status and the potential benefits and possible risks of vaccination.
In clinical trials, common adverse reactions in infants receiving PEDIARIX included injection-site reactions (pain, redness, and swelling), fever, drowsiness, irritability/fussiness, and loss of appetite.
Vaccination with PEDIARIX may not result in protection in all vaccine recipients.
